Difference between revisions of "MreBH"

From SubtiWiki
Jump to: navigation, search
Line 45: Line 45:
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[SigI regulon]]}}
+
{{SubtiWiki regulon|[[SigI regulon]]}},
 +
{{SubtiWiki regulon|[[WalR regulon]]}}
  
 
=The gene=
 
=The gene=
Line 80: Line 81:
 
* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
Line 123: Line 124:
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** induced by heat ([[SigI]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/18156261 PubMed]
 
 
** expression is increased in an ''[[ugtP]]'' mutant {{PubMed|22362028}}
 
** expression is increased in an ''[[ugtP]]'' mutant {{PubMed|22362028}}
 +
** induced at high temperature ([[SigI]], [[WalR]]) {{PubMed|24125693,18156261}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[WalR]]: transcription activation {{PubMed|24125693}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
Line 146: Line 148:
 
=Labs working on this gene/protein=
 
=Labs working on this gene/protein=
  
[[Peter Graumann]], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]
 
  
 
=Your additional remarks=
 
=Your additional remarks=
Line 154: Line 155:
 
<pubmed> 17064365,  20566861 21636744,21636745 22362028 </pubmed>
 
<pubmed> 17064365,  20566861 21636744,21636745 22362028 </pubmed>
 
==Other original publications==
 
==Other original publications==
<pubmed>16950129,19643765 ,16950129 18156261, 19659933 21091501 22069484 23879732 23869552</pubmed>
+
<pubmed>16950129,19643765 ,16950129 18156261, 19659933 21091501 22069484 23879732 23869552 24125693</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:33, 23 December 2013

  • Description: cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme complex, , required for LytE activity

Gene name mreBH
Synonyms
Essential no
Product cell shape-determining protein
Function cell shape determation
Gene expression levels in SubtiExpress: mreBH
Interactions involving this protein in SubtInteract: MreBH
MW, pI 35 kDa, 5.239
Gene length, protein length 1005 bp, 335 aa
Immediate neighbours ykpC, abh
Sequences Protein DNA DNA_with_flanks
Genetic context
MreBH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MreBH expression.png















Categories containing this gene/protein

cell shape, heat shock proteins, membrane proteins

This gene is a member of the following regulons

SigI regulon, WalR regulon

The gene

Basic information

  • Locus tag: BSU14470

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • forms ring-shaped filaments in a heterologous system PubMed
    • required for the activity of LytE PubMed
  • Protein family: ftsA/mreB family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:
  • Localization:
    • during logarithmic growth, MreBH forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis PubMed
    • forms transverse bands as cells enter the stationary phase PubMed
    • close to the inner surface of the cytoplasmic membrane PubMed
    • reports on helical structures formed by MreBH PubMed seem to be misinterpretation of data PubMed
    • normal localization depends on the presence of glucolipids, MreB forms irregular clusters in an ugtP mutant PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Localization

Other original publications