Difference between revisions of "ComP"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[pgsB]]-[[pgsC]]-[[pgsA]]'' operon {{PubMed|24296669}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' eight transmembrane segments | + | * '''[[Domains]]:''' eight transmembrane segments |
* '''Modification:''' autophosphorylation on a His residue | * '''Modification:''' autophosphorylation on a His residue | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' [[ComX]] (extracellular) | * '''Effectors of protein activity:''' [[ComX]] (extracellular) | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 comP] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 comP] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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<pubmed>12576575 </pubmed> | <pubmed>12576575 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>11133937,8643670,12067344,10094672,10419951,2116363,9274030 18763711 | + | <pubmed>11133937,8643670,12067344,10094672,10419951,2116363,9274030 18763711 24296669 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:05, 4 December 2013
- Description: two-component sensor kinase, detects extracellular ComX
| Gene name | comP |
| Synonyms | |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of genetic competence and quorum sensing |
| Gene expression levels in SubtiExpress: comP | |
| Interactions involving this protein in SubtInteract: ComP | |
| MW, pI | 89 kDa, 7.997 |
| Gene length, protein length | 2307 bp, 769 aa |
| Immediate neighbours | comA, comX |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
genetic competence, protein modification, transcription factors and their control, quorum sensing, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31690
Phenotypes of a mutant
- the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the pgsB-pgsC-pgsA operon PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of ComA
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: eight transmembrane segments
- Modification: autophosphorylation on a His residue
- Effectors of protein activity: ComX (extracellular)
- Localization: cell membrane PubMed
Database entries
- Structure:
- UniProt: Q99027
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: comP PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
Original Publications
Jia Mun Chan, Sarah B Guttenplan, Daniel B Kearns
Defects in the flagellar motor increase synthesis of poly-γ-glutamate in Bacillus subtilis.
J Bacteriol: 2014, 196(4);740-53
[PubMed:24296669]
[WorldCat.org]
[DOI]
(I p)
Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711]
[WorldCat.org]
[DOI]
(I p)
Mireille Ansaldi, Darja Marolt, Tina Stebe, Ines Mandic-Mulec, David Dubnau
Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants.
Mol Microbiol: 2002, 44(6);1561-73
[PubMed:12067344]
[WorldCat.org]
[DOI]
(P p)
P Tortosa, L Logsdon, B Kraigher, Y Itoh, I Mandic-Mulec, D Dubnau
Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system.
J Bacteriol: 2001, 183(2);451-60
[PubMed:11133937]
[WorldCat.org]
[DOI]
(P p)
F Piazza, P Tortosa, D Dubnau
Mutational analysis and membrane topology of ComP, a quorum-sensing histidine kinase of Bacillus subtilis controlling competence development.
J Bacteriol: 1999, 181(15);4540-8
[PubMed:10419951]
[WorldCat.org]
[DOI]
(P p)
C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672]
[WorldCat.org]
[DOI]
(P p)
Bauke Oudega, Gregory Koningstein, Luísa Rodrigues, Maria de Sales Ramon, Helmut Hilbert, Andreas Düsterhöft, Thomas M Pohl, Thomas Weitzenegger
Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).
Microbiology (Reading): 1997, 143 ( Pt 8);2769-2774
[PubMed:9274030]
[WorldCat.org]
[DOI]
(P p)
M Perego, J A Hoch
Cell-cell communication regulates the effects of protein aspartate phosphatases on the phosphorelay controlling development in Bacillus subtilis.
Proc Natl Acad Sci U S A: 1996, 93(4);1549-53
[PubMed:8643670]
[WorldCat.org]
[DOI]
(P p)
Y Weinrauch, R Penchev, E Dubnau, I Smith, D Dubnau
A Bacillus subtilis regulatory gene product for genetic competence and sporulation resembles sensor protein members of the bacterial two-component signal-transduction systems.
Genes Dev: 1990, 4(5);860-72
[PubMed:2116363]
[WorldCat.org]
[DOI]
(P p)
