YhcZ

• Description: two-component response regulator
  
  

Gene name	yhcZ
Synonyms
Essential	no
Product	two-component response regulator
Function	unknown
Gene expression levels in SubtiExpress: yhcZ
Interactions involving this protein in SubtInteract: YhcZ
MW, pI	23 kDa, 5.897
Gene length, protein length	642 bp, 214 aa
Immediate neighbours	yhcY, yhdA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

• Locus tag: BSU09330

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on a Asp residue by YhcY

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YhcY-YhcZ

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07528

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yhcY-yhcZ-yhdA PubMed

• Expression browser: yhcZ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism: LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Diana Wolf, Falk Kalamorz, Tina Wecke, Anna Juszczak, Ulrike Mäder, Georg Homuth, Sina Jordan, Janine Kirstein, Michael Hoppert, Birgit Voigt, Michael Hecker, Thorsten Mascher
In-depth profiling of the LiaR response of Bacillus subtilis.
J Bacteriol: 2010, 192(18);4680-93
[PubMed:20639339] [WorldCat.org] [DOI] (I p)

Sina Jordan, Anja Junker, John D Helmann, Thorsten Mascher
Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system.
J Bacteriol: 2006, 188(14);5153-66
[PubMed:16816187] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)