Difference between revisions of "SR4"
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| − | * '''Description:''' antitoxin RNA, inhibits'' [[bsrG]]'' | + | * '''Description:''' antitoxin RNA, inhibits'' [[bsrG]]'' translation and causes destabilization of the ''[[bsrG]]'' mRNA <br/><br/> |
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=The RNA= | =The RNA= | ||
| − | + | binds the ''[[bsrG]]'' mRNA and triggers its degradation {{PubMed|22229825}}, moreover SR4 inhibits ''[[bsrG]]'' translation {{PubMed|23969414}} | |
| − | binds the ''[[bsrG]]'' mRNA and triggers its degradation {{PubMed|22229825}} | ||
=Expression and regulation= | =Expression and regulation= | ||
Revision as of 15:20, 28 August 2013
| Gene name | SR4 |
| Synonyms | |
| Essential | no |
| Product | antitoxin RNA |
| Function | inhibition of BsrG toxin expression |
| Gene length | 180 bp |
| Immediate neighbours | bsrG, yokL |
| Get the DNA sequence | |
| Genetic context File:BsrG context.gif This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
toxins, antitoxins and immunity against toxins, SPß prophage, ncRNA
This gene is a member of the following regulons
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
- cell lysis on agar plates PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: no entry
- Structure:
Additional information
The RNA
binds the bsrG mRNA and triggers its degradation PubMed, moreover SR4 inhibits bsrG translation PubMed
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
Labs working on this gene/RNA
Sabine Brantl, Jena, Germany
Your additional remarks
References
Natalie Jahn, Sabine Brantl
One antitoxin--two functions: SR4 controls toxin mRNA decay and translation.
Nucleic Acids Res: 2013, 41(21);9870-80
[PubMed:23969414]
[WorldCat.org]
[DOI]
(I p)
Natalie Jahn, Heike Preis, Christoph Wiedemann, Sabine Brantl
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.
Mol Microbiol: 2012, 83(3);579-98
[PubMed:22229825]
[WorldCat.org]
[DOI]
(I p)
