Difference between revisions of "Elongasome"

Revision as of 12:50, 16 July 2013

A protein complex that catalyzes peptidoglycan biosynthesis and is thereby involved in maintaining cell shape

cell wall biosynthetic enzymes at the outer side of the membrane: penicillin-binding proteins (PbpA, PbpH, perhaps also PbpC, DacC, PbpI)
transmembrane proteins: MreC, MreD, RodA, RodZ, they couple the cytosolic actin-like proteins to the extracellular peptidoglycan-synthesizing machinery
actin-like proteins at the inner surface of the membrane: MreB, MreBH, Mbl, the polymers control/restrict the mobility of the cell wall elongation enzyme complex

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 ==Important publications==
-* [http://www.ncbi.nlm.nih.gov/pubmed/21636744 Domínguez-Escobar ''et al''.] from [[Rut Carballido-Lopez]]' lab and [http://www.ncbi.nlm.nih.gov/pubmed/21636745 Garner ''et al''.] report that movement of actin-like filaments is driven by the peptidoglycan elongation machinery. Both papers suggest that the [[MreB]]-like filaments serve to restrict the mobility of the peptidoglycan synthesizing machinery<br/>
+<pubmed>21636744 21636745 23848140 21725336 </pubmed>
-<pubmed>21636744 21636745</pubmed>
-* A comment on these papers:
-<pubmed> 21725336 </pubmed>
 ==Back to [[SubtInteract]]==