Difference between revisions of "ECF transporter"

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(The substrate-specific S components of the ECF transporters)
(Important reviews and publications)
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== Important reviews and publications ==
 
== Important reviews and publications ==
<pubmed>23584589 , 21135102, 20497229, </pubmed>
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<pubmed>23584589 , 21135102, 20497229, 18931129 </pubmed>

Revision as of 08:29, 15 July 2013

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transport proteins


ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins. In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.

The general components of the ECF transporters

  • ybxA ATP-binding A1 protein (EcfA1)
  • ybaE ATP-binding A2 protein (EcfA2)
  • ybaF membrane-spanning T protein (EcfT)

The substrate-specific S components of the ECF transporters

  • RibU: uptake of riboflavin
  • ThiT: uptake of thiamine
  • YhfU: uptake of biotin
  • TrpP: uptake of tryptophan
  • YuiG: unknown specificity, may also transport biotin

Important reviews and publications