Difference between revisions of "HemQ"
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Revision as of 14:51, 16 May 2013
- Description: heme-binding protein, essential for heme biosynthesis
| Gene name | hemQ |
| Synonyms | ipa-87r, ywfI |
| Essential | no |
| Product | heme-binding protein |
| Function | biosynthesis of heme |
| Gene expression levels in SubtiExpress: hemQ | |
| MW, pI | 29 kDa, 4.972 |
| Gene length, protein length | 762 bp, 254 aa |
| Immediate neighbours | pta, bacG |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis of cofactors, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU37670
Phenotypes of a mutant
defect in heme biosynthesis
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0447 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation on Ser-41 PubMed
- Cofactor(s): heme
- Effectors of protein activity:
Database entries
- Structure: 1TOT (Geobacillus stearothermophilus)
- UniProt: P39645
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: hemQ PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Tamara A Dailey, Tye O Boynton, Angela-Nadia Albetel, Svetlana Gerdes, Michael K Johnson, Harry A Dailey
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
J Biol Chem: 2010, 285(34);25978-86
[PubMed:20543190]
[WorldCat.org]
[DOI]
(I p)
Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307]
[WorldCat.org]
[DOI]
(P p)
E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933]
[WorldCat.org]
[DOI]
(P p)
