Mta

• Description: transcriptional activator of multidrug-efflux transporter genes, activates ymfD expression
  
  

Gene name	mta
Synonyms	ywnD
Essential	no
Product	transcriptional activator
Function	regulation of multidrug-efflux transporter genes
Gene expression levels in SubtiExpress: mta
MW, pI	29 kDa, 4.949
Gene length, protein length	771 bp, 257 aa
Immediate neighbours	clsA, ywnC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

Mta regulon

The gene

Basic information

• Locus tag: BSU36600

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1JBG (N-terminal domain), 1R8D (complex of N-terminal domain with DNA)

• UniProt: P71039

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mta PubMed

• Expression browser: mta PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • positive autoregulation PubMed

• Regulatory mechanism:
  • Mta: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Richard Brennan, Houston, Texas, USA Homepage