Difference between revisions of "CsoR"
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Revision as of 14:34, 16 May 2013
Gene name | csoR |
Synonyms | yvgZ |
Essential | no |
Product | transcription repressor |
Function | control of copper homeostasis |
Gene expression levels in SubtiExpress: csoR | |
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis | |
MW, pI | 11 kDa, 7.299 |
Gene length, protein length | 303 bp, 101 aa |
Immediate neighbours | copZ, yvaA |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals
This gene is a member of the following regulons
The CsoR regulon:
The gene
Basic information
- Locus tag: BSU33520
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: Cu(I) ions cause release of CsoR from its operator sites
Database entries
- Structure:
- UniProt: O32222
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Mohamed Marahiel, Marburg University, Germany homepage
Your additional remarks
References
Reviews
Corinna Rademacher, Bernd Masepohl
Copper-responsive gene regulation in bacteria.
Microbiology (Reading): 2012, 158(Pt 10);2451-2464
[PubMed:22918892]
[WorldCat.org]
[DOI]
(I p)
Original publications
Shashi Chillappagari, Andreas Seubert, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel, Marcus Miethke
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
J Bacteriol: 2010, 192(10);2512-24
[PubMed:20233928]
[WorldCat.org]
[DOI]
(I p)
Zhen Ma, Darin M Cowart, Robert A Scott, David P Giedroc
Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis.
Biochemistry: 2009, 48(15);3325-34
[PubMed:19249860]
[WorldCat.org]
[DOI]
(I p)
Shashi Chillappagari, Marcus Miethke, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
J Bacteriol: 2009, 191(7);2362-70
[PubMed:19168619]
[WorldCat.org]
[DOI]
(I p)
Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925]
[WorldCat.org]
[DOI]
(P p)