CzcD

• Description: cation diffusion facilitator
  
  

Gene name	czcD
Synonyms	yrdO
Essential	no
Product	cation diffusion facilitator
Function	cation efflux, resistence against Zn, Cu, Co, Ni
Gene expression levels in SubtiExpress: czcD
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	34 kDa, 5.859
Gene length, protein length	933 bp, 311 aa
Immediate neighbours	trkA, yrdN
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), resistance against toxic metals, membrane proteins

This gene is a member of the following regulons

CzrA regulon

The gene

Basic information

• Locus tag: BSU26650

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07084

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: czcD-trkA PubMed

• Expression browser: czcD PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) (CzrA) PubMed

• Regulatory mechanism:
  • CzrA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)