Difference between revisions of "Ldt"

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Revision as of 13:08, 16 May 2013

  • Description: L,D-transpeptidase involved in cell wall synthesis

Gene name ldt
Synonyms ykuD
Essential no
Product L,D-transpeptidase
Function cell wall biosynthesis
Gene expression levels in SubtiExpress: ldt
MW, pI 17 kDa, 10.252
Gene length, protein length 492 bp, 164 aa
Immediate neighbours ykuC, ykuE
Sequences Protein DNA DNA_with_flanks
Genetic context
YkuD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ldt expression.png
























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, sporulation proteins

This gene is a member of the following regulons

CcpA regulon, SigK regulon

The gene

Basic information

  • Locus tag: BSU14040

Expression

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: LysM repeat (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (3.3-fold) (CcpA) PubMed
    • expressed during sporulation in the mother cell (SigK) PubMed
  • Regulatory mechanism: CcpA: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)

Sophie Magnet, Ana Arbeloa, Jean-Luc Mainardi, Jean-Emmanuel Hugonnet, Martine Fourgeaud, Lionel Dubost, Arul Marie, Vanessa Delfosse, Claudine Mayer, Louis B Rice, Michel Arthur
Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes.
J Biol Chem: 2007, 282(18);13151-9
[PubMed:17311917] [WorldCat.org] [DOI] (P p)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)

T Kodama, H Takamatsu, K Asai, N Ogasawara, Y Sadaie, K Watabe
Synthesis and characterization of the spore proteins of Bacillus subtilis YdhD, YkuD, and YkvP, which carry a motif conserved among cell wall binding proteins.
J Biochem: 2000, 128(4);655-63
[PubMed:11011148] [WorldCat.org] [DOI] (P p)