PhrF

• Description: response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction
  
  

Gene name	phrF
Synonyms	ywhI
Essential	no
Product	phosphatase (RapF) regulator
Function	control of ComA activity
Gene expression levels in SubtiExpress: phrF
Interactions involving this protein in SubtInteract: PhrF
MW, pI	4 kDa, 10.237
Gene length, protein length	117 bp, 39 aa
Immediate neighbours	rapF, ywhH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, transcription factors and their control, quorum sensing, short peptides

This gene is a member of the following regulons

ComA regulon, SigH regulon

The gene

Basic information

• Locus tag: BSU37470

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds to RapF, this results in the inability of RapF to interact with ComA PubMed

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RapF-PhrF PubMed

• Localization:

Database entries

• Structure:

• UniProt: P71001

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rapF-phrF PubMed
  • phrF PubMed

• Expression browser: phrF PubMed

• Sigma factor:
  • phrF: SigH PubMed

• Regulation:
  • PhrF accumulates at high cell density

• Regulatory mechanism:
  • ComA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: