MmgA

• Description: degradative acetoacetyl-CoA thiolase
  
  

Gene name	mmgA
Synonyms	yqiL
Essential	no
Product	degradative acetoacetyl-CoA thiolase
Function	mother cell metabolism, leucine utilization
Gene expression levels in SubtiExpress: mmgA
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	41 kDa, 5.904
Gene length, protein length	1179 bp, 393 aa
Immediate neighbours	mmgB, yqiK
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins, utilization of amino acids

This gene is a member of the following regulons

CcpA regulon, SigE regulon

The gene

Basic information

• Locus tag: BSU24170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 acetyl-CoA = CoA + acetoacetyl-CoA PubMed

• Protein family: thiolase family (according to Swiss-Prot)

• Paralogous protein(s): FadA, YhfS

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3SS6 (the protein of B. anthracis, 44% identity, 73% similarity)

• UniProt: P45855

• KEGG entry: [3]

• E.C. number: 2.3.1.9

Expression and regulation

• Operon: mmgA-mmgB-mmgC-mmgD-mmgE-yqiQ PubMed

• Expression browser: mmgA PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed early during sporulation in the mother cell (SigE) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: