NucA

• Description: membrane-associated nuclease, catalyzes DNA cleavage during transformation
  
  

Gene name	nucA
Synonyms	comI
Essential	no
Product	membrane-associated nuclease
Function	genetic transformation, DNA uptake
Gene expression levels in SubtiExpress: nucA
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	16 kDa, 4.677
Gene length, protein length	441 bp, 147 aa
Immediate neighbours	nin, tlpC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU03430

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • integral membrane protein PubMed

Database entries

• Structure:

• UniProt: P12667

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: nucA-nin PubMed

• Expression browser: nucA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: