Difference between revisions of "DltC"
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38520 dltC] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 8 kDa, 3.621 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 8 kDa, 3.621 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dltB]]'', ''[[dltD]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dltB]]'', ''[[dltD]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38520 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38520 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38520 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:dltC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:dltC_context.gif]] | ||
Revision as of 14:11, 13 May 2013
- Description: D-alanine carrier protein, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides
| Gene name | dltC |
| Synonyms | ipa-3r |
| Essential | no |
| Product | D-alanine carrier protein |
| Function | biosynthesis of teichoic acid |
| Gene expression levels in SubtiExpress: dltC | |
| MW, pI | 8 kDa, 3.621 |
| Gene length, protein length | 234 bp, 78 aa |
| Immediate neighbours | dltB, dltD |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon
The gene
Basic information
- Locus tag: BSU38520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P39579
- KEGG entry: [3]
- E.C. number: 6.1.1.13
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Juergen J May, Robert Finking, Frank Wiegeshoff, Thomas T Weber, Nina Bandur, Ulrich Koert, Mohamed A Marahiel
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall.
FEBS J: 2005, 272(12);2993-3003
[PubMed:15955059]
[WorldCat.org]
[DOI]
(P p)
Min Cao, John D Helmann
The Bacillus subtilis extracytoplasmic-function sigmaX factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides.
J Bacteriol: 2004, 186(4);1136-46
[PubMed:14762009]
[WorldCat.org]
[DOI]
(P p)
M Perego, P Glaser, A Minutello, M A Strauch, K Leopold, W Fischer
Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.
J Biol Chem: 1995, 270(26);15598-606
[PubMed:7797557]
[WorldCat.org]
[DOI]
(P p)
