Difference between revisions of "TsaD"
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|style="background:#ABCDEF;" align="center"|'''Function''' || tRNA modification | |style="background:#ABCDEF;" align="center"|'''Function''' || tRNA modification | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU05940 tsaD] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/TsaD TsaD] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/TsaD TsaD] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydiD]]'', ''[[ydiF]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydiD]]'', ''[[ydiF]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU05940 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU05940 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU05940 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:gcp_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:gcp_context.gif]] | ||
Revision as of 12:15, 13 May 2013
- Description: required for threonyl carbamoyl adenosine (t6A) modification of tRNAs that pair with ANN codons in mRNA (together with TsaC), universally conserved protein
| Gene name | tsaD |
| Synonyms | ydiE, gcp |
| Essential | yes PubMed |
| Product | tRNA modification enzyme |
| Function | tRNA modification |
| Gene expression levels in SubtiExpress: tsaD | |
| Interactions involving this protein in SubtInteract: TsaD | |
| MW, pI | 36 kDa, 5.016 |
| Gene length, protein length | 1038 bp, 346 aa |
| Immediate neighbours | ydiD, ydiF |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
translation, essential genes, universally conserved proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU05940
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O05518
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Publications on the corresponding protein from other species
Ting Lei, Junshu Yang, Li Zheng, Todd Markowski, Bruce A Witthuhn, Yinduo Ji
The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis.
PLoS One: 2012, 7(10);e46836
[PubMed:23056478]
[WorldCat.org]
[DOI]
(I p)
Ting Lei, Xudong Liang, Junshu Yang, Meiying Yan, Li Zheng, Bruce Walcheck, Yinduo Ji
The C-terminal domain of the novel essential protein Gcp is critical for interaction with another essential protein YeaZ of Staphylococcus aureus.
PLoS One: 2011, 6(5);e20163
[PubMed:21625506]
[WorldCat.org]
[DOI]
(I p)
Tobias Bergmiller, Rafael Peña-Miller, Alexander Boehm, Martin Ackermann
Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD.
BMC Microbiol: 2011, 11;118
[PubMed:21619589]
[WorldCat.org]
[DOI]
(I e)
Basma El Yacoubi, Isabelle Hatin, Christopher Deutsch, Tamer Kahveci, Jean-Pierre Rousset, Dirk Iwata-Reuyl, Alexey G Murzin, Valérie de Crécy-Lagard
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification.
EMBO J: 2011, 30(5);882-93
[PubMed:21285948]
[WorldCat.org]
[DOI]
(I p)
Madhusudhan Srinivasan, Preeti Mehta, Yao Yu, Evelyn Prugar, Eugene V Koonin, A Wali Karzai, Rolf Sternglanz
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.
EMBO J: 2011, 30(5);873-81
[PubMed:21183954]
[WorldCat.org]
[DOI]
(I p)
Chen Katz, Ifat Cohen-Or, Uri Gophna, Eliora Z Ron
The ubiquitous conserved glycopeptidase Gcp prevents accumulation of toxic glycated proteins.
mBio: 2010, 1(3);
[PubMed:20824107]
[WorldCat.org]
[DOI]
(I e)
Jennifer I Handford, Bérengère Ize, Grant Buchanan, Gareth P Butland, Jack Greenblatt, Andrew Emili, Tracy Palmer
Conserved network of proteins essential for bacterial viability.
J Bacteriol: 2009, 191(15);4732-49
[PubMed:19376873]
[WorldCat.org]
[DOI]
(I p)
