ScpB

• Description: DNA segregation and condensation protein
  
  

Gene name	scpB
Synonyms	ypuH
Essential	no
Product	DNA segregation and condensation protein
Function	maintenance of chromosome structure
Gene expression levels in SubtiExpress: scpB
Interactions involving this protein in SubtInteract: ScpB
MW, pI	21 kDa, 4.25
Gene length, protein length	591 bp, 197 aa
Immediate neighbours	ypuI, scpA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU23210

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: scpB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms dimers PubMed
  • ScpB-Smc PubMed, this interaction takes place only in the presence of ScpA PubMed
  • ScpA-ScpB PubMed

• Localization:
  • nucleoid (Multiple) PubMed
  • the (Smc)2-ScpA-ScpB complex forms two bipolar assemblies on the chromosome, one in each cell half PubMed

Database entries

• Structure:
  • 4I98 (complex between ScpA (aa 1-160)-ScpB (aa 1-183) PubMed

• UniProt: P35155

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: scpA-scpB-ypuI PubMed

• Expression browser: scpB PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed