Difference between revisions of "ScpA"
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** present as stable monomer {{PubMed|22385855}} | ** present as stable monomer {{PubMed|22385855}} | ||
| − | ** [[ScpA]]-[[Smc]] {{PubMed|22385855,12100548}} | + | ** [[ScpA]]-[[Smc]] {{PubMed|23353789,22385855,12100548}} |
** [[ScpA]]-[[ScpB]] {{PubMed|12100548}} | ** [[ScpA]]-[[ScpB]] {{PubMed|12100548}} | ||
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* '''Structure:''' | * '''Structure:''' | ||
| + | ** [http://www.pdb.org/pdb/explore/explore.do?structureId=3ZGX 3ZGX] (complex between the head domain of [[Smc]] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [[ScpA]]) {{PubMed|23353789}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/P35154 P35154] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P35154 P35154] | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=scpA_2425831_2426586_-1 scpA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=scpA_2425831_2426586_-1 scpA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
| − | <pubmed>22385855</pubmed> | + | <pubmed>22385855 23353789 </pubmed> |
<pubmed>12100548,12421306,12065423,7934830, 16479537, 19450516 15009890 11948165</pubmed> | <pubmed>12100548,12421306,12065423,7934830, 16479537, 19450516 15009890 11948165</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:40, 1 February 2013
- Description: DNA segregation and condensation protein
| Gene name | scpA |
| Synonyms | ypuG |
| Essential | yes PubMed |
| Product | DNA segregation and condensation protein |
| Function | maintenance of chromosome structure |
| Gene expression levels in SubtiExpress: scpA | |
| Interactions involving this protein in SubtInteract: ScpA | |
| MW, pI | 29 kDa, 4.788 |
| Gene length, protein length | 753 bp, 251 aa |
| Immediate neighbours | scpB, ypuF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA condensation/ segregation, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23220
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: scpA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot), Nucleoid (Multiple) PubMed
Database entries
- Structure:
- UniProt: P35154
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Frank Bürmann, Ho-Chul Shin, Jérôme Basquin, Young-Min Soh, Victor Giménez-Oya, Yeon-Gil Kim, Byung-Ha Oh, Stephan Gruber
An asymmetric SMC-kleisin bridge in prokaryotic condensin.
Nat Struct Mol Biol: 2013, 20(3);371-9
[PubMed:23353789]
[WorldCat.org]
[DOI]
(I p)
M E Fuentes-Perez, E J Gwynn, M S Dillingham, F Moreno-Herrero
Using DNA as a fiducial marker to study SMC complex interactions with the atomic force microscope.
Biophys J: 2012, 102(4);839-48
[PubMed:22385855]
[WorldCat.org]
[DOI]
(I p)
