Difference between revisions of "Universally conserved proteins"
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'''These proteins are present in all genomes sequenced so far, from archaea and bacteria to man. So, one can say, that there is no life on earth without this small set of proteins. The genes encoding these proteins are usually essential.''' | '''These proteins are present in all genomes sequenced so far, from archaea and bacteria to man. So, one can say, that there is no life on earth without this small set of proteins. The genes encoding these proteins are usually essential.''' | ||
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==Glycolytic enzymes== | ==Glycolytic enzymes== | ||
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[[ArgS]], [[PheS]], [[GltX]] | [[ArgS]], [[PheS]], [[GltX]] | ||
| − | == | + | ==tRNA modification== |
| − | * [[ | + | * [[TsaE]] tRNA modification enzyme |
==Note== | ==Note== | ||
[[FtsZ]] has long been considered to be universally conserved. However, recently some ''Mycoplasma'' species lacking [[FtsZ]] have been found. | [[FtsZ]] has long been considered to be universally conserved. However, recently some ''Mycoplasma'' species lacking [[FtsZ]] have been found. | ||
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| + | ==Important publications== | ||
| + | <pubmed> 15479782 </pubmed> | ||
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| + | =Back to [[categories]]= | ||
Latest revision as of 15:29, 18 October 2012
These proteins are present in all genomes sequenced so far, from archaea and bacteria to man. So, one can say, that there is no life on earth without this small set of proteins. The genes encoding these proteins are usually essential.
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Contents
Glycolytic enzymes
Ribosomal proteins
RplA, RplB, RplC, RplE, RplF, RplK, RplN, RplR, RplV, RpsB, RpsC, RpsD, RpsE, RpsG, RpsH, RpsJ, RpsM, RpsQ, RpsS
Cellular processes
Nucleotide metabolism
- Prs phosphoribosyl-PP-synthetase
- Apt adenine phosphoribosyltransferase
- TruA pseudouridylate synthase
Aminoacyl tRNA synthetases
tRNA modification
- TsaE tRNA modification enzyme
Note
FtsZ has long been considered to be universally conserved. However, recently some Mycoplasma species lacking FtsZ have been found.
Important publications
Michael Y Galperin, Eugene V Koonin
'Conserved hypothetical' proteins: prioritization of targets for experimental study.
Nucleic Acids Res: 2004, 32(18);5452-63
[PubMed:15479782]
[WorldCat.org]
[DOI]
(I e)
