HtrA

• Description: membrane-anchored protein quality control protease, serine protease Do
  
  

Gene name	htrA
Synonyms	ykdA
Essential	no
Product	serine protease Do
Function	protein quality control
Gene expression levels in SubtiExpress: htrA
Metabolic function and regulation of this protein in SubtiPathways: Stress, Protein secretion
MW, pI	47 kDa, 4.699
Gene length, protein length	1347 bp, 449 aa
Immediate neighbours	ykcC, proG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, heat shock proteins, membrane proteins

This gene is a member of the following regulons

CssR regulon

The gene

Basic information

• Locus tag: BSU12900

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: PDZ (DHR) domain (according to Swiss-Prot)

• Paralogous protein(s): YyxA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)
  • extracellular (signal peptide) PubMed
  • randomly distributed in foci throughout the cell surface PubMed

Database entries

• Structure:

• UniProt: O34358

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: htrA (according to DBTBS)

• Expression browser: htrA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of secretion stress (CssR) PubMed
  • induced by rhamnolipids PubMed

• Regulatory mechanism:
  • CssR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A933 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed