Smc

• Description: chromosome condensation and segregation SMC protein
  
  

Gene name	smc
Synonyms	ylqA
Essential	yes PubMed
Product	chromosome condensation and segregation SMC protein
Function	structural maintenance of the chromosome
Gene expression levels in SubtiExpress: smc
Interactions involving this protein in SubtInteract: Smc
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	135 kDa, 5.266
Gene length, protein length	3558 bp, 1186 aa
Immediate neighbours	rnc, ftsY
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation, essential genes

The gene

Basic information

• Locus tag: BSU15940

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: SMC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms dimers PubMed
  • ScpA-Smc PubMed
  • ScpB-Smc, PubMed, this interaction takes place only in the presence of ScpA PubMed
  • Smc is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed

• Localization: nucleoid (heterogeneous) PubMed

Database entries

• Structure:

• UniProt: P51834

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rnc-smc-ftsY PubMed

• Expression browser: smc PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A822 ( smc::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Peter L Graumann, Tobias Knust
Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair.
Chromosome Res: 2009, 17(2);265-75
[PubMed:19308706] [WorldCat.org] [DOI] (I p)

Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950] [WorldCat.org] [DOI] (I p)

Original publications

M E Fuentes-Perez, E J Gwynn, M S Dillingham, F Moreno-Herrero
Using DNA as a fiducial marker to study SMC complex interactions with the atomic force microscope.
Biophys J: 2012, 102(4);839-48
[PubMed:22385855] [WorldCat.org] [DOI] (I p)