FadR

• Description: transcriptional repressor (TetR family), regulation of fatty acid degradation
  
  

Gene name	fadR
Synonyms	ysiA
Essential	no
Product	transcriptional repressor
Function	regulation of fatty acid degradation
Gene expression levels in SubtiExpress: fadR
Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation
MW, pI	21 kDa, 6.118
Gene length, protein length	582 bp, 194 aa
Immediate neighbours	fadB, lcfA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of lipids, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, FadR regulon

The gene

Basic information

• Locus tag: BSU28550

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94548

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • lcfA-fadR-fadB-etfB-etfA PubMed
  • fadR-fadB-etfB-etfA PubMed

• Expression browser: fadR PubMed

• Sigma factor:
  • lcfA: SigA PubMed
  • fadR: SigA PubMed

• Regulation:
  • induced by long-chain fatty acids (FadR) PubMed
  • subject to carbon catabolite repression (CcpA-HPr(Ser-P) PubMed

• Regulatory mechanism:
  • FadR: transcription repression PubMed
  • CcpA-HPr(Ser-P): transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A853 ( fadR::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Original publications

Additional publications: PubMed

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)