Difference between revisions of "FtsH"
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00690 ftsH] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00690 ftsH] | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/FtsH FtsH] | ||
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
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{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}, | {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}, | ||
{{SubtiWiki category|[[heat shock proteins]]}}, | {{SubtiWiki category|[[heat shock proteins]]}}, | ||
| + | {{SubtiWiki category|[[biofilm formation]]}}, | ||
{{SubtiWiki category|[[membrane proteins]]}} | {{SubtiWiki category|[[membrane proteins]]}} | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | * defective in biofilm formation {{PubMed|22882210}} | |
| − | strongly reduced sporulation frequency | + | * strongly reduced sporulation frequency {{PubMed|22142536}} |
=== Database entries === | === Database entries === | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[SpoVM]]-[[FtsH]] {{PubMed|10913836}} | ||
| + | ** [[FloT]]-[[FtsH]] {{PubMed|22882210}} | ||
| + | ** [[FloA]]-[[FtsH]] {{PubMed|22882210}} | ||
| + | ** [[FtsH]]-[[Spo0E]] {{PubMed|22142536}} | ||
| + | ** [[FtsH]]-[[Spo0M]] {{PubMed|22142536}} | ||
| − | * '''[[Localization]]:''' cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | + | * '''[[Localization]]:''' |
| + | ** cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | ||
| + | ** division septum {{PubMed|22882210}} | ||
=== Database entries === | === Database entries === | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed] | + | * '''Additional information:''' |
| + | ** the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed] | ||
| + | ** the [[FtsH]] levels are reduced in a ''[[floT]] [[floA]]'' double mutant {{PubMed|22882210}} | ||
=Biological materials = | =Biological materials = | ||
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=References= | =References= | ||
| − | <pubmed>10913836,12533473,9076729,10851010,9084181,15386101,10077851,19332814,12884008,7608085,9352926,, 19332814, 18763711 12176385 18179421 22142536 </pubmed> | + | <pubmed>10913836,12533473,9076729,10851010,9084181,15386101,10077851,19332814,12884008,7608085,9352926,, 19332814, 18763711 12176385 18179421 22142536 22882210 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:31, 14 August 2012
- Description: ATP-dependent metalloprotease
| Gene name | ftsH |
| Synonyms | |
| Essential | no |
| Product | ATP-dependent metalloprotease |
| Function | cell division, sporulation initiation |
| Gene expression levels in SubtiExpress: ftsH | |
| Interactions involving this protein in SubtInteract: FtsH | |
| Metabolic function and regulation of this protein in SubtiPathways: Phosphorelay, Stress | |
| MW, pI | 70 kDa, 5.841 |
| Gene length, protein length | 1911 bp, 637 aa |
| Immediate neighbours | hprT, coaX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell division, cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, biofilm formation, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00690
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
- Protein family:
- Paralogous protein(s): YjoB
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: P37476
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: induced by heat shock (class III)
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
