Difference between revisions of "ComX"
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|style="background:#ABCDEF;" align="center"| '''Product''' || competence pheromone precursor | |style="background:#ABCDEF;" align="center"| '''Product''' || competence pheromone precursor | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || quorum sensing | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[quorum sensing]] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU31700 comX] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU31700 comX] | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ComX ComX] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 4.358 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 4.358 | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' is synthesized as an inactive precursor, cleaved, and modified ( | + | * '''Modification:''' is synthesized as an inactive precursor, cleaved, and modified (prenylated) by [[ComQ]] prior to excretion {{PubMed|22878193}} |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[ComQ]]-[[ComX]] {{PubMed|22878193}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
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==Original publications== | ==Original publications== | ||
'''Additional publications:''' {{PubMed|22511326,21636272}} | '''Additional publications:''' {{PubMed|22511326,21636272}} | ||
| − | <pubmed>16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685, 1715859 </pubmed> | + | <pubmed>16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685, 1715859 22878193</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:25, 12 August 2012
- Description: competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin
| Gene name | comX |
| Synonyms | |
| Essential | no |
| Product | competence pheromone precursor |
| Function | quorum sensing |
| Gene expression levels in SubtiExpress: comX | |
| Interactions involving this protein in SubtInteract: ComX | |
| MW, pI | 6 kDa, 4.358 |
| Gene length, protein length | 165 bp, 55 aa |
| Immediate neighbours | comP, comQ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
genetic competence, quorum sensing
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31700
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: is synthesized as an inactive precursor, cleaved, and modified (prenylated) by ComQ prior to excretion PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- secreted (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P45453
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
The ComX --> surfactin signaling pathway is an example for paracrine signaling in bacteria
References
Reviews
Elizabeth Anne Shank, Roberto Kolter
Extracellular signaling and multicellularity in Bacillus subtilis.
Curr Opin Microbiol: 2011, 14(6);741-7
[PubMed:22024380]
[WorldCat.org]
[DOI]
(I p)
Original publications
Additional publications: PubMed
