CwlK

• Description: peptidoglycan hydrolytic L,D-endopeptidase
  
  

Gene name	cwlK
Synonyms	ycdD
Essential	no
Product	peptidoglycan hydrolytic L,D-endopeptidase
Function	cell wall turnover
Gene expression levels in SubtiExpress: cwlK
MW, pI	18 kDa, 5.66
Gene length, protein length	501 bp, 167 aa
Immediate neighbours	ycdC, rapJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall degradation/ turnover, membrane proteins

The gene

Basic information

• Locus tag: BSU02810

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase M15C family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: O34360

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: cwlK PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Ciaran Condon, IBPC, Paris, France Homepage

References

Tatsuya Fukushima, Yang Yao, Toshihiko Kitajima, Hiroki Yamamoto, Junichi Sekiguchi
Characterization of new L,D-endopeptidase gene product CwlK (previous YcdD) that hydrolyzes peptidoglycan in Bacillus subtilis.
Mol Genet Genomics: 2007, 278(4);371-83
[PubMed:17588176] [WorldCat.org] [DOI] (P p)