Difference between revisions of "MtlD"

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* '''Description:''' mannitol-1-phosphate 5-dehydrogenase <br/><br/>
  
 
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|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol utilization  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol utilization  
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03990 mtlD]
 
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
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|colspan="2" | '''Genetic context''' <br/> [[Image:mtlD_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:mtlD_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mtlD_451618_452739_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:mtlD_expression.png|500px]]
 
 
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* '''Operon:''' ''[[mtlA]]-[[mtlF]]-[[mtlD]]'' {{PubMed|12897001}}
 
* '''Operon:''' ''[[mtlA]]-[[mtlF]]-[[mtlD]]'' {{PubMed|12897001}}
  
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mtlD_451618_452739_1 mtlD] {{PubMed|22383849}}
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Revision as of 11:23, 7 August 2012

  • Description: mannitol-1-phosphate 5-dehydrogenase

Gene name mtlD
Synonyms mtlB
Essential no
Product mannitol-1-phosphate 5-dehydrogenase
Function mannitol utilization
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 40 kDa, 6.291
Gene length, protein length 1098 bp, 366 aa
Immediate neighbours mtlF, ycsA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MtlD context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

MtlR regulon

The gene

Basic information

  • Locus tag: BSU03990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH (according to Swiss-Prot)
  • Protein family: mannitol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3H2Z (from Shigella flexneri 2a str. 2457t mutant, 42% identity, 59% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Philippe Joyet, Meriem Derkaoui, Sandrine Poncet, Josef Deutscher
Control of Bacillus subtilis mtl operon expression by complex phosphorylation-dependent regulation of the transcriptional activator MtlR.
Mol Microbiol: 2010, 76(5);1279-94
[PubMed:20444094] [WorldCat.org] [DOI] (I p)

Shouji Watanabe, Miyuki Hamano, Hiroshi Kakeshita, Keigo Bunai, Shigeo Tojo, Hirotake Yamaguchi, Yasutaro Fujita, Sui-Lam Wong, Kunio Yamane
Mannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assimilation in Bacillus subtilis: possible cooperation of mtl and gut operons.
J Bacteriol: 2003, 185(16);4816-24
[PubMed:12897001] [WorldCat.org] [DOI] (P p)

Jonathan Reizer, Steffi Bachem, Aiala Reizer, Maryvonne Arnaud, Milton H Saier, Jörg Stülke
Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis.
Microbiology (Reading): 1999, 145 ( Pt 12);3419-3429
[PubMed:10627040] [WorldCat.org] [DOI] (P p)

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