Difference between revisions of "GcaD"
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| − | + | * '''Description:''' bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase<br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || cell wall metabolism | |style="background:#ABCDEF;" align="center"|'''Function''' || cell wall metabolism | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/pathways/murein/index.html Murein recycling]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)], [http://subtiwiki.uni-goettingen.de/pathways/murein/index.html Murein recycling]''' | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:gcaD_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:gcaD_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' ''[[gcaD]]-[[prs]]-[[ctc]]'' [http://www.ncbi.nlm.nih.gov/pubmed/8522540 PubMed] | * '''Operon:''' ''[[gcaD]]-[[prs]]-[[ctc]]'' [http://www.ncbi.nlm.nih.gov/pubmed/8522540 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/pubmed/8522540 PubMed] |
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* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 10:12, 7 August 2012
- Description: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase
| Gene name | gcaD |
| Synonyms | tms, tms26 |
| Essential | yes PubMed |
| Product | bifunctional N-acetylglucosamine-1-phosphate
uridyltransferase/glucosamine-1-phosphate acetyltransferase |
| Function | cell wall metabolism |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Murein recycling | |
| MW, pI | 49 kDa, 5.65 |
| Gene length, protein length | 1368 bp, 456 aa |
| Immediate neighbours | spoVG, prs |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00500
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P14192
- KEGG entry: [3]
- E.C. number: 2.7.7.23
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
I Hilden, B N Krath, B Hove-Jensen
Tricistronic operon expression of the genes gcaD (tms), which encodes N-acetylglucosamine 1-phosphate uridyltransferase, prs, which encodes phosphoribosyl diphosphate synthetase, and ctc in vegetative cells of Bacillus subtilis.
J Bacteriol: 1995, 177(24);7280-4
[PubMed:8522540]
[WorldCat.org]
[DOI]
(P p)
B Hove-Jensen
Identification of tms-26 as an allele of the gcaD gene, which encodes N-acetylglucosamine 1-phosphate uridyltransferase in Bacillus subtilis.
J Bacteriol: 1992, 174(21);6852-6
[PubMed:1328164]
[WorldCat.org]
[DOI]
(P p)
