RasP

• Description: intramembrane protease, cleaves FtsL and RsiW as well as signal peptides after release of the secreted proteins
  
  

Gene name	rasP
Synonyms	yluC
Essential	no
Product	intramembrane protease
Function	control of cell division and SigW activity
Gene expression levels in SubtiExpress: rasP
Interactions involving this protein in SubtInteract: RasP
MW, pI	46 kDa, 5.14
Gene length, protein length	1266 bp, 422 aa
Immediate neighbours	ispC, proS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, proteolysis, sigma factors and their control, membrane proteins

The gene

Basic information

• Locus tag: BSU16560

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • cleaves FtsL and RsiW
  • cleaves signal peptides after release of the secreted proteins PubMed

• Protein family: peptidase M50B family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RasP-FtsL, RasP-RsiW

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: O31754

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: rasP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Thomas Wiegert, University of Bayreuth, Germany Homepage

References

Reviews

Additional reviews: PubMed

Gu Chen, Xu Zhang
New insights into S2P signaling cascades: regulation, variation, and conservation.
Protein Sci: 2010, 19(11);2015-30
[PubMed:20836086] [WorldCat.org] [DOI] (I p)