Difference between revisions of "PabA"
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| − | + | * '''Description:''' para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II) <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate and tryptophan | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate and tryptophan | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PabA PabA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PabA PabA] | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:pabA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:pabA_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' ''[[pabB]]-[[pabA]]-[[pabC]]-[[sul]]-[[folB]]-[[folK]]-[[yazB]]-[[yacF]]-[[lysS]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | * '''Operon:''' ''[[pabB]]-[[pabA]]-[[pabC]]-[[sul]]-[[folB]]-[[folK]]-[[yazB]]-[[yacF]]-[[lysS]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] |
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* '''Regulation:''' translation repressed by tryptophan ([[MtrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | * '''Regulation:''' translation repressed by tryptophan ([[MtrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed] | ||
Revision as of 09:26, 7 August 2012
- Description: para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II)
| Gene name | pabA |
| Synonyms | trpG, trpX |
| Essential | no |
| Product | para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II) glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II) |
| Function | biosynthesis of folate and tryptophan |
| Interactions involving this protein in SubtInteract: PabA | |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp, Folate | |
| MW, pI | 21 kDa, 4.782 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | pabB, pabC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, biosynthesis of cofactors
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00750
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P28819
- KEGG entry: [3]
- E.C. number: 2.6.1.85
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Paul Babitzke, Carol S Baker, Tony Romeo
Regulation of translation initiation by RNA binding proteins.
Annu Rev Microbiol: 2009, 63;27-44
[PubMed:19385727]
[WorldCat.org]
[DOI]
(I p)
Paul Gollnick, Paul Babitzke, Alfred Antson, Charles Yanofsky
Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis.
Annu Rev Genet: 2005, 39;47-68
[PubMed:16285852]
[WorldCat.org]
[DOI]
(P p)
Original Publications
Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. Mol Microbiol. 2011 81(6): 1459-1473. PubMed:21815947
