Moonlighting proteins

Moonlighting proteins are proteins that have secondary ("hidden") functions in addition to their primary functions. Many glycolytic proteins have moonlighting activities.

A special class of moonlighting proteins are trigger enzymes that control gene expression in addition to their enzymatic function.

Moonlighting proteins in B. subtilis

• trigger enzymes
• Eno
• PfkA

Reviews on moonlighting proteins

Shelley D Copley
Moonlighting is mainstream: paradigm adjustment required.
Bioessays: 2012, 34(7);578-88
[PubMed:22696112] [WorldCat.org] [DOI] (I p)

Constance J Jeffery
Moonlighting proteins--an update.
Mol Biosyst: 2009, 5(4);345-50
[PubMed:19396370] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Jörg Stülke
Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression.
Mol Microbiol: 2008, 67(4);692-702
[PubMed:18086213] [WorldCat.org] [DOI] (P p)

Constance J Jeffery
Mass spectrometry and the search for moonlighting proteins.
Mass Spectrom Rev: 2005, 24(6);772-82
[PubMed:15605385] [WorldCat.org] [DOI] (P p)

Constance J Jeffery
Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins.
Curr Opin Struct Biol: 2004, 14(6);663-8
[PubMed:15582389] [WorldCat.org] [DOI] (P p)

Brandon d Moore
Bifunctional and moonlighting enzymes: lighting the way to regulatory control.
Trends Plant Sci: 2004, 9(5);221-8
[PubMed:15130547] [WorldCat.org] [DOI] (P p)

Shelley D Copley
Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Curr Opin Chem Biol: 2003, 7(2);265-72
[PubMed:12714060] [WorldCat.org] [DOI] (P p)

C J Jeffery
Moonlighting proteins.
Trends Biochem Sci: 1999, 24(1);8-11
[PubMed:10087914] [WorldCat.org] [DOI] (P p)