Difference between revisions of "ComX"

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Revision as of 08:19, 23 April 2012

  • Description: competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin

Gene name comX
Synonyms
Essential no
Product competence pheromone precursor
Function quorum sensing
MW, pI 6 kDa, 4.358
Gene length, protein length 165 bp, 55 aa
Immediate neighbours comP, comQ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComX context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComX expression.png
























Categories containing this gene/protein

genetic competence, quorum sensing

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU31700

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: is synthesized as an inactive precursor, cleaved, and modified (isoprenylated) by ComQ prior to excretion
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

The ComX --> surfactin signaling pathway is an example for paracrine signaling in bacteria

References

Reviews

Elizabeth Anne Shank, Roberto Kolter
Extracellular signaling and multicellularity in Bacillus subtilis.
Curr Opin Microbiol: 2011, 14(6);741-7
[PubMed:22024380] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed