YwpB

• Description: β-hydroxyacyl-(acyl carrier protein) dehydratase
  
  

Gene name	ywpB
Synonyms	fabZ
Essential	no
Product	β-hydroxyacyl-ACP dehydratase
Function	fatty acid biosynthesis
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	14 kDa, 9.36
Gene length, protein length	396 bp, 132 aa
Immediate neighbours	mscL, rapD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of lipids

The gene

Basic information

• Locus tag: BSU36370

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: FabZ subfamily (according to Swiss-Prot)

• Paralogous protein(s): YcsD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3D6X (from Campylobacter jejuni, 45% identity, 67% similarity) PubMed

• UniProt: P94584

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ywpB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Andrew S Kirkpatrick, Takeshi Yokoyama, Kyoung-Jae Choi, Hye-Jeong Yeo
Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).
Biochem Biophys Res Commun: 2009, 380(2);407-12
[PubMed:19280690] [WorldCat.org] [DOI] (I p)

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)