Difference between revisions of "GpsA"
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Revision as of 09:05, 16 April 2012
- Description: glycerol-3-phosphate dehydrogenase (NAD)
| Gene name | gpsA |
| Synonyms | |
| Essential | yes PubMed |
| Product | glycerol-3-phosphate dehydrogenase (NAD) |
| Function | biosynthesis of phospholipids |
| Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
| MW, pI | 37 kDa, 6.231 |
| Gene length, protein length | 1035 bp, 345 aa |
| Immediate neighbours | yphE, yphC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis of lipids, essential genes,
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22830
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H (according to Swiss-Prot)
- Protein family: NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm PubMed
Database entries
- Structure: 3K96 (from Coxiella burnetii RSA 493, 37% identity, 59% similarity)
- UniProt: P46919
- KEGG entry: [2]
- E.C. number: 1.1.1.94
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965]
[WorldCat.org]
[DOI]
(P p)
H R Morbidoni, D de Mendoza, J E Cronan
Synthesis of sn-glycerol 3-phosphate, a key precursor of membrane lipids, in Bacillus subtilis.
J Bacteriol: 1995, 177(20);5899-905
[PubMed:7592341]
[WorldCat.org]
[DOI]
(P p)
