KduI

• Description: 5-keto-4-deoxyuronate isomerase
  
  

Gene name	kduI
Synonyms
Essential	no
Product	5-keto-4-deoxyuronate isomerase
Function	utilization of galacturonic acid
MW, pI	30 kDa, 5.115
Gene length, protein length	825 bp, 275 aa
Immediate neighbours	kdgR, kduD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, KdgR regulon

The gene

Basic information

• Locus tag: BSU22130

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate (according to Swiss-Prot)

• Protein family: PNP/MTAP phosphorylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P50843

• KEGG entry: [2]

• E.C. number: 5.3.1.17

Expression and regulation

• Operon: kduI-kduD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by galacturonate (KdgR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • KdgR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jer-Sheng Lin, Gwo-Chyuan Shaw
Regulation of the kduID operon of Bacillus subtilis by the KdgR repressor and the ccpA gene: identification of two KdgR-binding sites within the kdgR-kduI intergenic region.
Microbiology (Reading): 2007, 153(Pt 3);701-710
[PubMed:17322190] [WorldCat.org] [DOI] (P p)