Difference between revisions of "CatR"
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| − | * '''Description:''' MarR/DUF24 | + | * '''Description:''' [[MarR/DUF24 family]] transcription repressor of the ''[[catD]]-[[catE]]'' operon <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || MarR/DUF24 | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[MarR/DUF24 family]]transcription repressor |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || resistance against oxidative and electrophile stress |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 9.887 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 9.887 | ||
| Line 63: | Line 63: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' MarR/DUF24 | + | * '''Catalyzed reaction/ biological activity:''' [[MarR/DUF24 family]] transcription repressor of the'' [[catD]]-[[catE]]'' operon {{PubMed|20639328}} |
| − | * '''Protein family:''' | + | * '''Protein family:''' [[MarR/DUF24 family]] |
* '''Paralogous protein(s):''' [[YodB]] | * '''Paralogous protein(s):''' [[YodB]] | ||
Revision as of 09:02, 17 January 2012
- Description: MarR/DUF24 family transcription repressor of the catD-catE operon
| Gene name | catR |
| Synonyms | yvaP |
| Essential | no |
| Product | MarR/DUF24 familytranscription repressor |
| Function | resistance against oxidative and electrophile stress |
| MW, pI | 26 kDa, 9.887 |
| Gene length, protein length | 708 bp, 236 aa |
| Immediate neighbours | yvaO, yvaQ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The CatR regulon:
The gene
Basic information
- Locus tag: BSU33680
Phenotypes of a mutant
increased resistance to catechol and quinones PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: MarR/DUF24 family transcription repressor of the catD-catE operon PubMed
- Protein family: MarR/DUF24 family
- Paralogous protein(s): YodB
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of catD-catE) PubMed
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O32238
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Haike Antelmann,University of Greifswald, Germany
Your additional remarks
References
Reviews
Antelmann H, Helmann JD. Thiol-based redox switches and gene regulation. Antioxid Redox Signal. 2011,14:1049-63. PubMed
Original Articles
Bui Khanh Chi, Kazuo Kobayashi, Dirk Albrecht, Michael Hecker, Haike Antelmann
The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis.
J Bacteriol: 2010, 192(18);4571-81
[PubMed:20639328]
[WorldCat.org]
[DOI]
(I p)
