Difference between revisions of "AdhR"
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| − | * '''Description:''' transcriptional activator of ''[[adhA]]-[[yraA]]'' <br/><br/> | + | * '''Description:''' MerR/NmlR-family transcriptional activator of ''[[adhA]]-[[yraA]]'', responsive to formaldehyde and methylglyoxal <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional activator | + | |style="background:#ABCDEF;" align="center"| '''Product''' || MerR/NmlR-family transcriptional activator |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of the protective response to formaldehyde | + | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of the protective response to formaldehyde and methylglyoxal |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.637 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.637 | ||
| Line 65: | Line 65: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | * '''Protein family:''' | + | * '''Protein family:'''MerR/NmlR-family of regulators |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
| Line 75: | Line 75: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' activity probably controlled via thiol-(S)-alkylation | + | * '''Modification:''' activity probably redox-controlled via thiol-(S)-alkylation at Cys-52 by aldehydes {{PubMed|19170879}} |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| Line 83: | Line 83: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | * '''[[Localization]]:''' | + | * '''[[Localization]]:''' cytoplasmic |
| − | |||
=== Database entries === | === Database entries === | ||
| Line 103: | Line 102: | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' | + | * '''Regulation:''' |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 124: | Line 123: | ||
=Labs working on this gene/protein= | =Labs working on this gene/protein= | ||
| + | |||
| + | [[Haike Antelmann]],University of Greifswald, Germany | ||
=Your additional remarks= | =Your additional remarks= | ||
Revision as of 17:25, 15 December 2011
- Description: MerR/NmlR-family transcriptional activator of adhA-yraA, responsive to formaldehyde and methylglyoxal
| Gene name | adhR |
| Synonyms | yraB |
| Essential | no |
| Product | MerR/NmlR-family transcriptional activator |
| Function | regulation of the protective response to formaldehyde and methylglyoxal |
| MW, pI | 16 kDa, 9.637 |
| Gene length, protein length | 420 bp, 140 aa |
| Immediate neighbours | yraD, adhA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU27000
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:MerR/NmlR-family of regulators
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: activity probably redox-controlled via thiol-(S)-alkylation at Cys-52 by aldehydes PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasmic
Database entries
- Structure:
- UniProt: O06008
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Haike Antelmann,University of Greifswald, Germany
Your additional remarks
References
