Difference between revisions of "DnaD"
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=== Additional information=== | === Additional information=== | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** [[DnaD]]-mediated untwisting of the DNA stimulates [[Nth]] endonuclease activity at AP sites {{PubMed|21954439}} | ||
* '''Protein family:''' DNA polymerase type-Y family (according to Swiss-Prot) | * '''Protein family:''' DNA polymerase type-Y family (according to Swiss-Prot) | ||
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=Expression and regulation= | =Expression and regulation= | ||
| − | + | '''Operon:''' ''[[dnaD]]-[[nth]]'' {{PubMed|21954439}} | |
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* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** constitutively expressed {{PubMed|21954439}} | ||
| + | ** expression is transiently increased after treatment with H2O2 {{PubMed|21954439}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
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=References= | =References= | ||
| − | <pubmed> 19707554,15686560,15186423,11585815, 20122408,16479537, 11222620 19968790 11679082 20587500 21097613 </pubmed> | + | <pubmed> 19707554,15686560,15186423,11585815, 20122408,16479537, 11222620 19968790 11679082 20587500 21097613 21954439</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:27, 30 September 2011
- Description: initiation of chromosome replication, part of the replisome
| Gene name | dnaD |
| Synonyms | |
| Essential | yes PubMed |
| Product | initiation of chromosome replication |
| Function | DNA replication |
| Interactions involving this protein in SubtInteract: DnaD | |
| MW, pI | 27 kDa, 7.174 |
| Gene length, protein length | 696 bp, 232 aa |
| Immediate neighbours | nth, asnS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22350
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: DNA polymerase type-Y family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: Membrane-proximal (Spotty) PubMed
Database entries
- Structure: 2C79 (N-terminal domain)
- UniProt: P39787
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
Operon: dnaD-nth PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
