PhrH

• Description: secreted regulator of the activity of phosphatase RapH
  
  

Gene name	phrH
Synonyms
Essential	no
Product	secreted regulator of the activity of phosphatase RapH
Function	control of sporulation initiation
Interactions involving this protein in SubtInteract: PhrH
MW, pI
Gene length, protein length
Immediate neighbours	rapH, yeeI
Gene sequence (+200bp)	Protein sequence
Genetic context File:PhrH context.gif

Categories containing this gene/protein

phosphorelay, quorum sensing, short peptides

This gene is a member of the following regulons

RghR regulon

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: no entry

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RapH-PhrH PubMed

• Localization:
  • secreted as hexapeptide TDRNTT PubMed, uptake by the (OppD-OppF)-(OppB-OppC)-OppA ABC transporter PubMed

Database entries

• Structure:

• UniProt: Q59HN7

• KEGG entry:

• E.C. number:

Expression and regulation

• Operon:
  • rapH-phrH PubMed
  • phrH PubMed

• Sigma factor:
  • rapH: SigA PubMed
  • phrH: SigA PubMed

• Regulation:
  • rapH: repressed by RghR PubMed

• Regulatory mechanism:
  • RghR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publikations: PubMed

Kentaro Hayashi, Tsukahara Kensuke, Kazuo Kobayashi, Naotake Ogasawara, Mitsuo Ogura
Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon.
Mol Microbiol: 2006, 59(6);1714-29
[PubMed:16553878] [WorldCat.org] [DOI] (P p)