Difference between revisions of "YabA"
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=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' negative control of replication initiation [ | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** negative control of replication initiation {{PubMed|12060778}} | ||
| + | ** associates with the ''oriC'' region in a [[DnaA]]-dependent manner, this limits the amount of [[DnaA]] that can bind the ''oriC'' region {{PubMed|21895792}} | ||
| + | ** YabA inhibits co-operative DNA binding by [[DnaA]] {{PubMed|21895792}} | ||
* '''Protein family:''' yabA family (according to Swiss-Prot) | * '''Protein family:''' yabA family (according to Swiss-Prot) | ||
| Line 80: | Line 81: | ||
* '''Cofactor(s):''' Zn cluster | * '''Cofactor(s):''' Zn cluster | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' |
| + | ** [[DnaN]] overexpression or release from the replisome decreases association of [[YabA]] with ''oriC'', increases association of [[DnaA]] with ''oriC'' {{PubMed|21895792}} | ||
| − | * '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed] | + | * '''[[SubtInteract|Interactions]]:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed] |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
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<pubmed> 20157337 </pubmed> | <pubmed> 20157337 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed> 19578359,,12060778 16461910, 19737352 19081080 </pubmed> | + | <pubmed> 19578359, 21895792,12060778 16461910, 19737352 19081080 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:01, 14 September 2011
| Gene name | yabA |
| Synonyms | |
| Essential | no |
| Product | negative regulator of replication initiation |
| Function | positioning of DnaA |
| Interactions involving this protein in SubtInteract: YabA | |
| MW, pI | 13 kDa, 6.065 |
| Gene length, protein length | 357 bp, 119 aa |
| Immediate neighbours | yaaT, yabB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00330
Phenotypes of a mutant
strongly reduced growth rate in minimal medium PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: yabA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: leucine zipper
- Modification:
- Cofactor(s): Zn cluster
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37542
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Philippe Noirot, Jouy-en-Josas, France Homepage
Alan Grossman, Cambridge, MA, USA Homepage
Your additional remarks
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
