Difference between revisions of "MreBH"
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| − | * '''Description:''' cell- | + | * '''Description:''' [[cell shape]]-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme comple<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || cell- | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[cell shape]]-determining protein |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || cell | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[cell shape]] determation |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 5.239 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 5.239 | ||
| Line 81: | Line 81: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[MreBH]]-[[LytE]] {{PubMed|16950129}} | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** part of the [[cell wall biosynthetic complex]] {{PubMed|21636744,21636745}} | ||
| + | ** [[MreBH]]-[[LytE]] {{PubMed|16950129}} | ||
| + | ** [[MreBH]]-[[Mbl]] {{PubMed|21636744}} | ||
| + | ** [[MreB]]-[[MreBH]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17064365 PubMed] | ||
* '''Localization:''' | * '''Localization:''' | ||
| − | ** forms | + | ** during logarithmic growth, [[MreBH]] forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis {{PubMed|21636744}} |
| − | ** | + | ** forms transverse bands as cells enter the stationary phase {{PubMed|21636744}} |
| + | ** close to the inner surface of the cytoplasmic membrane [http://www.ncbi.nlm.nih.gov/sites/entrez/16950129 PubMed] | ||
| + | ** reports on helical structures formed by MreBH {{PubMed|16950129,20566861}} seem to be misinterpretation of data {{PubMed|21636744}} | ||
=== Database entries === | === Database entries === | ||
| Line 133: | Line 139: | ||
=References= | =References= | ||
==Localization== | ==Localization== | ||
| − | <pubmed> 17064365, 20566861 | + | <pubmed> 17064365, 20566861 21636744,21636745 </pubmed> |
==Other original publications== | ==Other original publications== | ||
<pubmed>16950129,19643765 ,16950129 18156261, 19659933 21091501</pubmed> | <pubmed>16950129,19643765 ,16950129 18156261, 19659933 21091501</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 05:21, 11 July 2011
- Description: cell shape-determining protein, forms filaments, the polymers control/restrict the mobility of the cell wall elongation enzyme comple
| Gene name | mreBH |
| Synonyms | |
| Essential | no |
| Product | cell shape-determining protein |
| Function | cell shape determation |
| MW, pI | 35 kDa, 5.239 |
| Gene length, protein length | 1005 bp, 335 aa |
| Immediate neighbours | ykpC, abh |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell shape, heat shock proteins, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU14470
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- forms ring-shaped filaments in a heterologous system PubMed
- Protein family: ftsA/mreB family (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- during logarithmic growth, MreBH forms discrete patches thst move processively along peripheral tracks perpendicular to the cell axis PubMed
- forms transverse bands as cells enter the stationary phase PubMed
- close to the inner surface of the cytoplasmic membrane PubMed
- reports on helical structures formed by MreBH PubMed seem to be misinterpretation of data PubMed
Database entries
- Structure:
- UniProt: P39763
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Peter Graumann, Freiburg University, Germany homepage
Your additional remarks
References
Localization
Other original publications
Hervé Joël Defeu Soufo, Peter L Graumann
Bacillus subtilis MreB paralogues have different filament architectures and lead to shape remodelling of a heterologous cell system.
Mol Microbiol: 2010, 78(5);1145-58
[PubMed:21091501]
[WorldCat.org]
[DOI]
(I p)
Yoshikazu Kawai, Kei Asai, Jeffery Errington
Partial functional redundancy of MreB isoforms, MreB, Mbl and MreBH, in cell morphogenesis of Bacillus subtilis.
Mol Microbiol: 2009, 73(4);719-31
[PubMed:19659933]
[WorldCat.org]
[DOI]
(I p)
Kathrin Schirner, Jeff Errington
Influence of heterologous MreB proteins on cell morphology of Bacillus subtilis.
Microbiology (Reading): 2009, 155(Pt 11);3611-3621
[PubMed:19643765]
[WorldCat.org]
[DOI]
(I p)
Chi-Ling Tseng, Gwo-Chyuan Shaw
Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis.
J Bacteriol: 2008, 190(5);1561-7
[PubMed:18156261]
[WorldCat.org]
[DOI]
(I p)
Rut Carballido-López, Alex Formstone, Ying Li, S Dusko Ehrlich, Philippe Noirot, Jeff Errington
Actin homolog MreBH governs cell morphogenesis by localization of the cell wall hydrolase LytE.
Dev Cell: 2006, 11(3);399-409
[PubMed:16950129]
[WorldCat.org]
[DOI]
(P p)
