Difference between revisions of "CsoR"
| Line 38: | Line 38: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | =The [[CsoR regulon]]:= | |
| + | * ''[[copZ]]-[[copA]]'', ''[[ycnJ]]'', ''[[yotD]]'' | ||
=The gene= | =The gene= | ||
| Line 54: | Line 55: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 67: | Line 65: | ||
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
| − | |||
| − | |||
| − | |||
| − | |||
=== Extended information on the protein === | === Extended information on the protein === | ||
Revision as of 10:41, 12 December 2010
| Gene name | csoR |
| Synonyms | yvgZ |
| Essential | no |
| Product | transcription repressor |
| Function | control of copper homeostasis |
| MW, pI | 11 kDa, 7.299 |
| Gene length, protein length | 303 bp, 101 aa |
| Immediate neighbours | copZ, yvaA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals
This gene is a member of the following regulons
The CsoR regulon:
The gene
Basic information
- Locus tag: BSU33520
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: Cu(I) ions cause release of CsoR from its operator sites
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O32222
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Mohamed Marahiel, Marburg University, Germany homepage
Your additional remarks
References
Shashi Chillappagari, Andreas Seubert, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel, Marcus Miethke
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
J Bacteriol: 2010, 192(10);2512-24
[PubMed:20233928]
[WorldCat.org]
[DOI]
(I p)
Zhen Ma, Darin M Cowart, Robert A Scott, David P Giedroc
Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis.
Biochemistry: 2009, 48(15);3325-34
[PubMed:19249860]
[WorldCat.org]
[DOI]
(I p)
Shashi Chillappagari, Marcus Miethke, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
J Bacteriol: 2009, 191(7);2362-70
[PubMed:19168619]
[WorldCat.org]
[DOI]
(I p)
Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925]
[WorldCat.org]
[DOI]
(P p)
