Difference between revisions of "CitZ"
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* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' phosphorylated on Ser-284 | + | * '''Modification:''' phosphorylated on Ser-284 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed] |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
Revision as of 16:46, 9 February 2009
- Description: citrate synthase
| Gene name | citZ |
| Synonyms | citA2 |
| Essential | no |
| Product | citrate synthase II |
| Function | TCA cycle |
| MW, pI | 41 kDa, 5.451 |
| Gene length, protein length | 1116 bp, 372 aa |
| Immediate neighbours | ytwI, icd |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
glutamate auxotrophy and a defect in sporulation PubMed
Database entries
- DBTBS entry: [[1]]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated on Ser-284 PubMed
- Cofactor(s):
- Effectors of protein activity: inhibited by ATP PubMed
- Interactions:
- Localization:
Database entries
- Structure: 2C6X (Structure of Bacillus Subtilis Citrate Synthase)
- Swiss prot entry:
- KEGG entry:
- E.C. number: 4.1.3.7
Additional information
Expression and regulation
- Sigma factor: SigA
- Regulation: catabolite repression (CcpA), repression by glucose + glutamate (CcpC) PubMed, repression under anaerobic conditions PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
Jörg Stülke, University of Göttingen, Germany Homepage
Your additional remarks
References
- Kim HJ, Roux A, Sonenshein AL (2002b) Direct and indirect roles of CcpA in regulation of Bacillus subtilis Krebs cycle genes. Mol Microbiol 45:179-190. PubMed
- Nakano MM, Zuber P, Sonenshein AL (1998) Anaerobic regulation of Bacillus subtilis Krebs cycle genes. J Bacteriol. 180: 3304-3311. PubMed
- Jin S, Sonenshein AL (1994) Identification of two distinct Bacillus subtilis citrate synthase genes J Bacteriol. 176: 4669-4679. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
