Difference between revisions of "ThiE"
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| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[biosynthesis of cofactors]]}} | ||
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| + | = This gene is a member of the following [[regulons]] = | ||
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=The protein= | =The protein= | ||
Revision as of 00:41, 9 December 2010
- Description: thiamine-phosphate diphosphorylase
| Gene name | thiE |
| Synonyms | thiC, ipa-26d, ywbK |
| Essential | no |
| Product | thiamine-phosphate diphosphorylase |
| Function | biosynthesis of thiamine by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate |
| Metabolic function and regulation of this protein in SubtiPathways: Thiamin | |
| MW, pI | 23 kDa, 5.058 |
| Gene length, protein length | 666 bp, 222 aa |
| Immediate neighbours | ywbL, thiM |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU38290
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate (according to Swiss-Prot)
- Protein family: TMP-PPase family (according to Swiss-Prot)
- Paralogous protein(s): TenI
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1G6C
- UniProt: P39594
- KEGG entry: [3]
- E.C. number: 2.5.1.3
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
