Difference between revisions of "MtlA"

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* '''Description:''' [[trigger enzymes|trigger enzyme]]: mannitol-specific [[PTS|phosphotransferase system]], EIICB of the [[PTS]]<br/><br/>
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* '''Description:''' [[trigger enzymes|trigger enzyme]]: mannitol-specific [[PTS|phosphotransferase system]], EIICB of the [[PTS]]&lt;br/>&lt;br/>
 
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol uptake and phosphorylation, control of [[MtlR]] activity
 
|style="background:#ABCDEF;" align="center"|'''Function''' || mannitol uptake and phosphorylation, control of [[MtlR]] activity
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: &lt;br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 65 kDa, 8.778   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 65 kDa, 8.778   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycnL]]'', ''[[mtlF]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycnL]]'', ''[[mtlF]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&amp;#91;EMBLCDS:CAB12206&amp;#93;+-newId sequences] &lt;br/> (Barbe ''et al.'', 2009)'''
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12206&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
 
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|colspan="2" | '''Genetic context''' &lt;br/> [[Image:mtlA_context.gif]]
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|colspan="2" | '''Genetic context''' <br/> [[Image:mtlA_context.gif]]
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  &lt;div align="right"> &lt;small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]&lt;/small>&lt;/div>
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  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
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__TOC__
 
__TOC__
  
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<br/><br/><br/><br/><br/><br/>
  
 
=The gene=
 
=The gene=
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=References=
 
=References=
  
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&lt;pubmed>12897001, 20444094, 10627040 , 17218307 &lt;/pubmed>
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<pubmed>12897001, 20444094, 10627040 , 17218307 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 04:52, 24 November 2010

Gene name mtlA
Synonyms
Essential no
Product trigger enzyme: mannitol-specific phosphotransferase system, EIICB
Function mannitol uptake and phosphorylation, control of MtlR activity
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 65 kDa, 8.778
Gene length, protein length 1830 bp, 610 aa
Immediate neighbours ycnL, mtlF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MtlA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU03981

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-559 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure: 1A3A (from Escherichia coli k12 mutant, 42% identity, 66% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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