Difference between revisions of "PolA"
(→References) |
|||
| Line 1: | Line 1: | ||
| − | * '''Description:''' DNA polymerase I <br/><br/> | + | * '''Description:''' DNA polymerase I, required for repair of UV- or MMS-induced DNA damage <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 52: | Line 52: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' has DNA polymerase and 5'-3' exonuclease activity, but no 3'-5' exonuclease activity {{PubMed|16045613}} |
* '''Protein family:''' DNA polymerase type-A family (according to Swiss-Prot) | * '''Protein family:''' DNA polymerase type-A family (according to Swiss-Prot) | ||
| Line 70: | Line 70: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''Interactions:''' [[PolA]]-[[PolY1]]-[[DnaN]] {{PubMed|16045613}}, [[PolA]]-[[PolY2]] {{PubMed|16045613}} |
* '''Localization:''' | * '''Localization:''' | ||
Revision as of 18:22, 3 November 2010
- Description: DNA polymerase I, required for repair of UV- or MMS-induced DNA damage
| Gene name | polA |
| Synonyms | |
| Essential | no |
| Product | DNA polymerase I |
| Function | DNA replication |
| MW, pI | 98 kDa, 4.916 |
| Gene length, protein length | 2640 bp, 880 aa |
| Immediate neighbours | mutM, phoR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU29090
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: has DNA polymerase and 5'-3' exonuclease activity, but no 3'-5' exonuclease activity PubMed
- Protein family: DNA polymerase type-A family (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure: 1XWL (large fragment, corresponds to AA 310 to 880, Geobacillus stearothermophilus)
- UniProt: O34996
- KEGG entry: [2]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
