Difference between revisions of "YvmC"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' cyclodipeptide synthase<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || cyclodipeptide synthase |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of the extracellular iron chelate pulcherrimin |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 6.612 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 6.612 | ||
| Line 53: | Line 53: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner {{PubMed|19430487}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
| Line 87: | Line 88: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | + | * '''Operon:''' ''[[yvmC]]-[[cypX]]'' [http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 Reference] | |
| − | * '''Operon:''' | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| Line 117: | Line 117: | ||
=References= | =References= | ||
| − | + | <pubmed> 19430487 4204912 </pubmed> | |
| + | [http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 additional paper] | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:22, 11 August 2010
- Description: cyclodipeptide synthase
| Gene name | yvmC |
| Synonyms | |
| Essential | no |
| Product | cyclodipeptide synthase |
| Function | biosynthesis of the extracellular iron chelate pulcherrimin |
| MW, pI | 28 kDa, 6.612 |
| Gene length, protein length | 744 bp, 248 aa |
| Immediate neighbours | cypX, yvmB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU35070
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34351
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Muriel Gondry, Ludovic Sauguet, Pascal Belin, Robert Thai, Rachel Amouroux, Carine Tellier, Karine Tuphile, Mickaël Jacquet, Sandrine Braud, Marie Courçon, Cédric Masson, Steven Dubois, Sylvie Lautru, Alain Lecoq, Shin-ichi Hashimoto, Roger Genet, Jean-Luc Pernodet
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
Nat Chem Biol: 2009, 5(6);414-20
[PubMed:19430487]
[WorldCat.org]
[DOI]
(I p)
R L Uffen, E Canale-Parola
Synthesis of pulcherriminic acid by Bacillus subtilis.
J Bacteriol: 1972, 111(1);86-93
[PubMed:4204912]
[WorldCat.org]
[DOI]
(P p)
