Difference between revisions of "MciZ"

From SubtiWiki
Jump to: navigation, search
Line 54: Line 54:
 
=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' inhibits GTPase activity of [[FtsZ]] and Z ring formation during sporulation {{PubMed|18284588}}
  
 
* '''Protein family:'''
 
* '''Protein family:'''
Line 72: Line 72:
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[MciZ]]-[[FtsZ]]
+
* '''Interactions:''' [[MciZ]]-[[FtsZ]] {{PubMed|18284588}}
  
 
* '''Localization:'''
 
* '''Localization:'''
Line 92: Line 92:
 
* '''Operon:'''  
 
* '''Operon:'''  
  
* '''[[Sigma factor]]:'''  
+
* '''[[Sigma factor]]:''' [[SigE]] {{PubMed|18284588}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** expressed early during sporulation in the mother cell ([[SigE]]) {{PubMed|18284588}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  

Revision as of 08:22, 8 August 2010

  • Description: FtsZ inhibition peptide

Gene name mciZ
Synonyms
Essential no
Product FtsZ inhibition peptide
Function inhibits GTPase activity of FtsZ and Z ring formation during sporulation
MW, pI 4.8 kDa, y.yy
Gene length, protein length 120 bp, 40 aa
Immediate neighbours nudF, yqkF
Gene sequence (+200bp) Protein sequence
Genetic context
NudF context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: no entry

Additional information

This gene was only recently identified. PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: inhibits GTPase activity of FtsZ and Z ring formation during sporulation PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: no entry
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • expressed early during sporulation in the mother cell (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)


Original Publications