Difference between revisions of "DltA"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
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* '''Operon:''' ''[[dltA]]-[[dltB]]-[[dltC]]-[[dltD]]-[[dltE]]'' {{PubMed|7797557}}
  
* '''Operon:''' ''[[dltA]]-[[dltB]]-[[dltC]]-[[dltD]]-[[dltE]]''
+
* '''[[Sigma factor]]:''' [[SigD]] {{PubMed|7797557}}, [[SigX]] {{PubMed|14762009}}
 
 
* '''[[Sigma factor]]:''' [[SigD]], [[SigX]]
 
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 
** [[RelA]] dependent downregulation (Class I) during stringent response {{PubMed|11948165}}
 
** [[RelA]] dependent downregulation (Class I) during stringent response {{PubMed|11948165}}
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/7797557 PubMed]
+
** repressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|7797557}}
  
* '''Regulatory mechanism:''' activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
+
* '''Regulatory mechanism:'''  
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/7797557 PubMed]
+
** activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
 +
** [[Spo0A]]: transcription repression {{PubMed|7797557}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 10:17, 6 February 2010

  • Description: D-alanyl-D-alanine carrier protein ligase

Gene name dltA
Synonyms ipa-5r, dae
Essential no
Product D-alanyl-D-alanine carrier protein ligase
Function biosynthesis of teichoic acid
MW, pI 55 kDa, 4.929
Gene length, protein length 1509 bp, 503 aa
Immediate neighbours menA, dltB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
DltA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU38500

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot)
  • Protein family: DltA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References