Difference between revisions of "RacA"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''racA'' (according to [http://dbtbs.hgc.jp/COG/prom/racA.html DBTBS]) |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigH]] {{PubMed|12493822}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** expressed under conditions that trigger sporulation ([[Spo0A]]) | + | ** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|12493822,14651647,15687200}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[Spo0A]]: transcription activation | + | ** [[Spo0A]]: transcription activation {{PubMed|12493822,14651647,15687200}} |
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 20:03, 2 February 2010
- Description: cell division protein: attaches the chromosome to the cell pole
| Gene name | racA |
| Synonyms | ywkC |
| Essential | no |
| Product | cell division protein |
| Function | cell division |
| MW, pI | 20 kDa, 9.514 |
| Gene length, protein length | 552 bp, 184 aa |
| Immediate neighbours | ywkD, ywkB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU37030
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: racA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: DisA
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P45870
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: racA (according to DBTBS)
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Rok Lenarcic, Sven Halbedel, Loek Visser, Michael Shaw, Ling Juan Wu, Jeff Errington, Davide Marenduzzo, Leendert W Hamoen
Localisation of DivIVA by targeting to negatively curved membranes.
EMBO J: 2009, 28(15);2272-82
[PubMed:19478798]
[WorldCat.org]
[DOI]
(I p)
Sigal Ben-Yehuda, Masya Fujita, Xiaole Shirley Liu, Boris Gorbatyuk, Dunja Skoko, Jie Yan, John F Marko, Jun S Liu, Patrick Eichenberger, David Z Rudner, Richard Losick
Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA.
Mol Cell: 2005, 17(6);773-82
[PubMed:15780934]
[WorldCat.org]
[DOI]
(P p)
Masaya Fujita, José Eduardo González-Pastor, Richard Losick
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.
J Bacteriol: 2005, 187(4);1357-68
[PubMed:15687200]
[WorldCat.org]
[DOI]
(P p)
Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647]
[WorldCat.org]
[DOI]
(P p)
Ling Juan Wu, Jeff Errington
RacA and the Soj-Spo0J system combine to effect polar chromosome segregation in sporulating Bacillus subtilis.
Mol Microbiol: 2003, 49(6);1463-75
[PubMed:12950914]
[WorldCat.org]
[DOI]
(P p)
Sigal Ben-Yehuda, David Z Rudner, Richard Losick
RacA, a bacterial protein that anchors chromosomes to the cell poles.
Science: 2003, 299(5606);532-6
[PubMed:12493822]
[WorldCat.org]
[DOI]
(I p)
