Difference between revisions of "FeuA"

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(Labs working on this gene/protein)
(Labs working on this gene/protein)
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=Labs working on this gene/protein=
 
=Labs working on this gene/protein=
  
[[Mohamed A. Marahiel]], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
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[[Mohamed Marahiel]], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
  
 
=Your additional remarks=
 
=Your additional remarks=

Revision as of 15:37, 6 January 2010

  • Description: ABC-transporter for the siderophores enterobactin and bacillibactin (binding protein), with YusV as ATPase

Gene name feuA
Synonyms
Essential no
Product ABC-transporter for the siderophores enterobactin
and bacillibactin (binding protein)
Function iron acquisition
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 34 kDa, 8.018
Gene length, protein length 951 bp, 317 aa
Immediate neighbours feuB, btr
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FeuA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU01630

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Fe/B12 periplasmic-binding domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot), extracellular (signal peptide) PubMed, membrane PubMed

Database entries

  • Structure: 2PHZ, 2WI8, 2WHY (complex with ferri-bacillibactin)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of iron (Fur, CitB) PubMed
    • induced in the presence of iron chelators bacillibactin or enterobactin (Btr) PubMed
  • Regulatory mechanism:
    • Fur: transcription repression PubMed
    • CitB: binding to the iron responsive element in the absence of iron
    • Btr: transcription activation in the presence of the co-activators bacillibactin or enterobactin PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References